One of our goals with PySoy is support games for everyday desktop and mobile users so our hardware requirements are quite low. Any modern video card or mobile device should support OpenGL ES 2.0.
See INSTALL in both the libsoy and pysoy source trees. This file contains our current dependencies and easy copy/paste command lines for most popular GNU/Linux distributions.
hg clone http://hg.pysoy.org/libsoy hg clone http://hg.pysoy.org/pysoy
Beyond the runtime dependencies, you will also need a copy of valac to compile the Genie source (.gs) to C source (.c). You will also need the C headers (.h) for all our runtime dependencies, Redhat and Debian based distributions (including Ubuntu and Fedora) provide these in separate *-dev packages.
Once all these requirements are met, you can use waf to build libsoy. Waf is self-contained in our source tree and only depends on Python to run:
./waf configure ./waf build sudo ./waf install
During the configure step waf will check to ensure all dependencies are met and report any that are missing.
PySoy itself depends only on Python 3.1+ and libsoy and is built using Distutils:
./setup.py build sudo ./setup.py install
With these steps you should be able to modify and test changes to the source. Join #PySoy on irc.freenode.net for help and how to commit improvements back to the Mercurial repository.